Since 2020, aggregated from related topics
Cortical spreading depression (CSD) is a slowly propagating wave of depolarization in the cerebral cortex that is associated with a transient cessation of neuronal activity. This phenomenon has been implicated in the pathophysiology of various neurological conditions, including migraine, stroke, and traumatic brain injury. CSD is characterized by a wave of depolarization followed by an extended period of neuronal suppression, leading to changes in blood flow, metabolism, and neurovascular coupling. Understanding the mechanisms underlying CSD could lead to the development of novel therapeutic strategies for treating and preventing neurological disorders.